6 Benefits of Sida acuta: Dosage & Safety

Sida acuta is a medicinal herb that has been used for thousands of years throughout many parts of the world. This article will look at the health benefits of Sida …

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Medical Review by: Daniel Powers, MS
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Sida acuta is a medicinal herb that has been used for thousands of years throughout many parts of the world.

This article will look at the health benefits of Sida acuta, as well as its safety and history.

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What is Sida acuta?

Sida acuta is commonly used to treat malaria and Lyme disease. The plant is also used to support liver health and has antibacterial and anti-ulcer properties.

Sida can be found in cultivated fields, waste areas, and along the roadside; it’s often seen as a weed. It has been used medicinally throughout the world, including Central America, India, and Africa.

The plant’s Latin name is Sida acuta, while its common name is common wireweed. It is also known as “sengh” in some parts of the world.

The major bioactive constituents in this herb include:

  • Cryptolepine (primary alkaloid)
  • Vasicine
  • Ferulic acid
  • Quindoline
  • Ephedrine
  • Saponosides
  • Coumarins
  • Steroids: ecdysterone, -sistosterol, stiglnaterol, ampesterol
  • Tannins
  • Phenolic compounds: evofolin-A & B
  • Triterpenoids

Health Benefits of Sida acuta:

Below are the top research-backed health benefits of Sida acuta and its bioactive compounds.

sida acuta benefits

1. May Treat Lyme Disease & Bartonellosis

Sida acuta is commonly used in herbal formulas for treating Lyme disease and its co-infections.

Lyme disease is a vector-borne disease caused by Borrelia burgdorferi and transmitted by a tick bite. One common co-infection is Bartonellosis, which is caused by the bacteria Bartonella.

Lyme disease expert and herbal author Stephen Harrod Buhner has an herbal protocol for treating Bartonella. Sida acuta is one of the main herbs used in the treatment due to its broad antimicrobial activity. Antimicrobial herbs can help treat Lyme disease and its co-infections in a number of ways, such as by inhibiting the growth of certain pathogens, eradicating the bacteria, and managing the symptoms of the infectious disease.


Herbal experts indicate that sida may work to treat lyme disease and its symptoms. Clinical research is needed for confirmation of Sida’s antibacterial activity.

2. May Treat Malaria

Sida acuta is known for its benefits in treating malaria. Malaria is a parasitic infection caused by the parasite Plasmodium falciparum and transmitted by mosquitoes.

An in vitro study evaluated five plant extracts, including Sida acuta, against the parasite Plasmodium falciparum. The extract of Sida showed the most activity against Plasmodium falciparum. Researchers attribute the results to sida’s alkaloid compounds, which are responsible for the plant’s antibacterial and antimalarial effects.

Another in vitro study confirmed this plant’s anti-plasmodial activity against Plasmodium falciparum, and again, researchers identified the plant’s alkaloid compound, cryptolepine, as a significant contributor to its potent activity. 


In vitro research has found that Sida acuta may effectively treat malaria. Human clinical trials are needed for verification.

3. Antimicrobial Properties

Sida acuta benefits the body through its antibacterial properties.

This antibacterial activity was demostrated in a study using Sida acuta extract against several microorganisms. The extract had a significant inhibitory effect against the bacteria Staphylococcus aureus, Bacillus subtilis, and Streptococcus faecalis.

Another study using Sida acuta extracts revealed antimicrobial activity against Staphylococcus aureus in patients with HIV/AIDS.

Researchers investigated the antibacterial activity of two alkaloid compounds in Sida, cryptolepine and quindoline. These alkaloids displayed antibacterial activity against several microorganisms such as Staphylococcus species, Bacillus cereus, Listeria innocua, Enterococcus faecalis, and Escherichia coli (E. coli).


Lab-based studies show that two alkaloid compounds found in Sida acuta may inhibit bacterial growth, but human research is required in order to confirm this finding.

4. May Support Healthy Liver Function

Sida acuta is known for its hepatoprotective properties (prevents liver damage).

An animal study revealed significant hepatoprotective effects with the treatment of Sida acuta. Results showed decreased liver biomarkers such as alkaline phosphatase (ALP) and bilirubin. The plant’s phenolic compound, ferulic acid, found in the root, is notably responsible for the hepatoprotective effects as it inhibits free radicals and acts as an antioxidant.


Animal research indicates that Sida acuta may possess hepatoprotective ability. Clinical trials, however, are needed for verification.

5. Other Potential Benefits:

  • May Have Anti-Diabetic Activity: In an animal study, Sida acuta extract exhibited cholesterol and blood sugar-lowering effects. Sida extract reduced diabetes-related acute inflammation in an animal study.
  • May Have Nephroprotective Properties: An in vitro study of Sida acuta extract showed to stop kidney stone growth.
  • May Have Neuroprotective/Anticonvulsant Properties: Sida acuta may have an impact on the central nervous system. An animal study revealed anxiolytic (anti-anxiety), anti-convulsant, and sedative effects.
  • May Have Anti-Ulcer Activity: An in vivo study demonstrated significant anti-ulcer effects of Sida acuta compared to the ulcer drug famotidine. Researchers believe the plant’s flavonoid compounds, tannins, steroids, and triterpenoids are responsible for the anti-ulcer activity.


Sida acuta have been tied to a wide variety of health benefits. Human clinical trials are needed to verify these findings.
sida health benefits

The Best Sida acuta Supplements:

As previously stated in this article, Sida may help to benefit the body in a variety of ways, especially for those with Lyme disease. Many people ask the question, what is the best Sida supplement?

The ideal way to supplement with Sida acuta is through a well-formulated herbal blend.

We recommend looking at Researched Nutritionals’ Myc-P Formula. Researched Nutritionals puts together well-crafted herbal blends for specific health interests. Their formula for Lyme disease is a great protocol that contains a blend of antimicrobial herbs.

You can pick up this Sida acuta herbal blend formula at Amazon, which offers competitive pricing and fast shipping.

Our Choice
Researched Nutritionals Myc-P - Targeted Microbial Support With Sida Acuta

A well-formulated blend of antimicrobial herbs, including Sida acuta, for Lyme disease support. Our go-to formula.

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Sida acuta Safety:

Sida acuta contains minimal amounts of ephedrine, which may potentially cause mild restlessness; therefore, this herbshould not be used with pharmaceuticals that have similar effects.

According to herbalist Stephen Buhner, Sida may interfere with diabetic medications as it is a hypoglycemic herb.

Pregnancy & Lactation:

Stephen Buhner states that it is not recommended to use Sida acuta during pregnancy or if you are trying to conceive. The plant is an abortifacient, meaning it may induce abortions.

There is no safety information on the use of Sida acuta during lactation.

Sida acuta Dosage:

Standard dosing for Sida acuta is as follows:

  • Tincture (1:5, 60% alcohol, dried leaf): Take 20 to 40 drops up to 4 times daily.
    • For a severe staph infection: Take ½ tsp. to 1 tbsp. 3 to 6 times per day for up to 60 days.
  • Tea: Add 1 to 2 tsp. of powdered leaves in 6 ounces of hot water. Allow steeping for 15 minutes. Drink 1 to 2 times per day.
    • For acute conditions: Drink up to 10 cups per day.

Stephen Buhner states that Sida acuta can increase fatigue. Reducing the dosage will help subside any fatigue.


Sida acuta is not on the United Plant Saver’s “species-at-risk list” of plants that are sensitive to the impact of human activities.

Naming & Taxonomy:

Sida acuta is the plant’s scientific name. It belongs to the Malvaceae (i.e., mallow) family of plants.

The herb is a small perennial plant with little yellow flowers, solitary or in pairs.

All parts of the plant are used medicinally (i.e., leaves, bark, root, seeds, and blossoms); however, the leaves are most commonly used.

Other plants in the this species include:

  • Sida rhombifolia
  • Sida alnifolia
  • Sida ulmifolia
  • Sida ovata
  • Sida cordifolia
  • Sida abutifolia
  • Sida elliottii

History & Traditional Use:

Sida acuta has been used for thousands of years. Indigenous people of tropical countries use different parts of this plant to treat health concerns, including rheumatic conditions, azoospermia (absence of sperm), oligospermia (low sperm count), wounds, sciatica, nervous and heart diseases, colds, coughs, asthma, tuberculosis, diabetes, and high blood pressure.

In Papua New Guinea, the fresh root is chewed on to cure dysentery (an infection of the intestines).

In Nicaragua, a tea of the plant is used to treat asthma, fever, aches, pains, and ulcers, and is used as an anti-worm agent. In addition, a decoction of the whole plant is used to treat ‘sexual diseases’.

In Cameroon, they believe the whole plant of Sida acuta contains anti-inflammatory, anti-rheumatic, diaphoretic, sedative, and anti-ulcer properties.

In Colombia and India, the whole plant is used to heal snake bites by decreasing the hemorrhagic effects of the venom.

Central Americans also treat malaria with a decoction of the whole plant and headaches with a topical plant poultice.

In India, the root is considered cooling, astringent, and tonic. It is used to promote appetite, assist digestion, reduce fever, and treat liver, bile, and blood disorders, as well as nervous and urinary diseases. 

The roots of Sida species plants are considered adaptogenic, immunomodulators, and a general nutritive tonic.

health benefits of Sida Acuta


Sida acuta has been traditionally used for thousands of years and is used for treating various ailments, including malaria, bacterial infections, ulcers, Lyme disease, and its co-infections. 

Most of this herb’s effects are supported by animal and lab-based research, as well as traditional reviews affirm the plant’s health benefits. More research, in particular human clinical trials, is needed.

It is recommended to always consult with your physician before adding a new herbal supplement to your regimen, especially if you take any medication.

Buhner, S. H. (2015). Healing Lyme: Natural healing of Lyme borreliosis and the coinfections chlamydia and spotted fever rickettsioses (2nd edition). Raven Press: Boulder, CO.

Feng, J., Leone, J., Schweig, S., & Zhang, Y. (2020). Evaluation of natural and botanical medicines for activity against growing and non-growing forms of B. burgdorferi. Frontiers in Medicine, 7(6). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050641/

Murali, S. & Deepa, N. (2022). A comprehensive review of Sida acuta: Potential plant of medical interest. European Journal of Molecular & Clinical Medicine, 9(3). https://www.ejmcm.com/article_18337_d9fbadffd5314dcd96ac630f55fbcec8.pdf

Sreedevi, C.D., Latha, P.G., Ancy, P., Suja, S.R., Shyamal, S., Shine, V.J., Sini, S., Anuja G.I, & Rajasekharan, S. (2009). Hepatoprotective studies on Sida acuta Burm. f. Journal of Ethnopharmacology, 124(2), 171-175. https://pubmed.ncbi.nlm.nih.gov/19422907/

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About Tara Bassi, MS, CNS, LDN

Tara is a Licensed Nutritionist and Clinical Herbalist, specializing in women’s health. She has a Master’s of Science in Clinical Nutrition and Herbal Medicine from Maryland University of Integrative Health and is a Board Certified Nutrition Specialist (CNS®).