The 8 Best Herbs for Lyme Disease

Lyme disease is a common condition and there are numerous herbs to help treat individuals suffering from Lyme disease. In this article, we will answer some common questions regarding Lyme …

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Medical Review by: Daniel Powers, MS
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Lyme disease is a common condition and there are numerous herbs to help treat individuals suffering from Lyme disease.

In this article, we will answer some common questions regarding Lyme disease and review the best herbs for Lyme disease.

herbs for lyme disease overview

Lyme Disease Overview:

In the United States, Lyme disease (or Lyme borreliosis) is the most common vector-borne disease with an estimated 30,000 reported cases annually.

Lyme disease is caused by the bacterium Borrelia burgdorfer, which is transmitted by black-legged ticks.

To transmit the Lyme disease bacteria, ticks need to be attached to their host for 36-48 hours. Ticks can attach to any part of the body, but can commonly be found in areas such as the groin, thighs, armpits, and scalp. 

It is important to remember that the tick must be infected in order to transmit Borrelia burgdorfer and cause Lyme disease.

Lyme disease infection is most common through nymphs and adult tick bites, although the infection can be transmitted through the larvae stage as well. Nymphs are tiny and more difficult to see than adults.

Spring, summer, and fall are the most common periods for tick bites.

Lyme disease can cause a vast range of symptoms:

  • Skin rash
  • Chills and fever
  • Fatigue
  • Headache
  • Muscle and joint pain
  • Neurological features
  • Cardiovascular symptoms

Early diagnosis and proper treatment are essential to help prevent the development of the late stages of Lyme disease and severe symptoms.

Best Herbs for Lyme Disease:

Below are the best herbs for Lyme disease and its co-infections supported by scientific research. 

Herbalists and practitioners who specialize in Lyme disease will often have a specific herbal protocol that uses a variety of the herbs below.

lyme disease herbs - japanese knotweed
Japanese Knotweed

1. Japanese Knotweed

Japanese knotweed (Polygonum cuspidatum) is a medicinal plant, commonly known as an invasive weed, and is native to Asian countries.

A study demonstrated that one of Japanese knotweed’s main compounds, emodin, can effectively stop the growth of the bacteria that causes Lyme disease.

Another similar study showed that Japanese knotweed has a strong impact on inhibiting the growth of the Lyme disease bacteria.

The disease Babesiosis is a common co-infection of Lyme disease. A study revealed that Japanese knotweed can stop the growth of the parasite that causes Babesiosis as well.

Lyme disease expert and herbal author, Stephen Harrod Buhner notes why Japanese knotweed is an effective treatment for Lyme disease through its ability to:

  • Improves blood flow
  • Reduces inflammation
  • Protects heart function
  • Provides anti-bacterial and anti-viral effects
  • Provides neuroprotective and regeneration effects


Clinical studies and traditional herbalism have found that the antibacterial and anti-inflammatory effects of Japanese knotweed may work to prevent the growth of the Lyme disease bacteria.

lyme disease herbs - cat's claw
Cat’s Claw

2. Cat’s Claw

Cat’s claw (Uncaria tomentosa) is a large vine medicinal plant native to the Amazon rainforest. 

A lab study has demonstrated that cat’s claw can inhibit the growth of the bacteria that causes Lyme disease.

Cat’s claw has been shown to reduce Lyme disease symptoms and ultimately eliminate the Lyme infection from the body in a six-month study.


Lab research indicates that cat’s claw herb may work to reduce the growth and symptoms of Lyme disease infections.
lyme disease herbs -chinese skullcap
Chinese Skullcap

3. Chinese Skullcap

Chinese skullcap (Scutellaria baicelensis) is a common medicinal plant used in Traditional Chinese Medicine (TCM).

A study found that Chinese skullcap has strong anti-microbial activity and the ability to stop the growth of the bacteria that causes Lyme disease.

Another study found that one of Chinese skullcap’s main compounds, baicalein, is an effective anti-microbial agent and can inhibit the progression of the Lyme disease bacteria.


Research has found that Chinese skullcap may possess antimicrobial properties that may make this herb effective in inhibiting the growth of Lyme disease bacteria.

lyme disease herbs - cistus incanus
Cistus Incanus

4. Cistus Incanus

Cistus incanus (or rock rose) is a medicinal plant native to the Mediterranean region.

A study showed that Cistus incanus can stop the growth of the bacteria that causes Lyme disease.

Stephen H. Buhner reports that Cistus incanus is commonly used in the treatment of Lyme disease due to its anti-microbial properties.


Herbalist Stephen Buhner mentions that cistus incanus is thought to halt the growth of the Lyme disease bacteria through its antimicrobial activities.

lyme disease herbs - red sage
Red Sage

5. Red Sage

Red sage (Salvia miltiorrhiza) is a medicinal plant native to China and Japan, used in Traditional Chinese Medicine (TCM).

Stephen H. Buhner explains the beneficial roles red sage plays in treating Lyme disease:

  • Has anti-bacterial properties
  • Has anti-inflammatory properties
  • Helps stop the breakdown of collagen and promotes tissue healing
  • Assists in lowering histamine levels, lessening disease progression


Herbal expert Stephen Buhner states that red sage may work to benefit Lyme disease through this herb’s antibacterial and anti-inflammatory effects.
lyme disease herbs - cryptolepis sanguinolenta
Cryptolepis sanguinolenta

6. Cryptolepis sanguinolenta

Cryptolepis sanguinolenta (or yellow-dye root) is a medicinal plant native to Africa.

A study showed that Cryptolepis sanquinolenta can halt the growth and eradicate the bacteria that causes Lyme disease.

Another study showed that Cryptolepis sanguinolenta can inhibit the growth of the parasite that causes Babesiosis (similar to Japanese knotweed), moreover, this herb had equal or better effects than commonly used antibiotic medications.


Studies show that Cryptolepis sanguinolenta may treat lyme disease through bacterial growth prevention.

lyme disease herbs - sida acuta
Sida acuta

7. Sida acuta

Sida acuta (or common wireweed) is a medicinal plant used throughout the world, although it is often seen as a weed.

Bartonellosis is another common co-infection of Lyme disease. Lyme expert Stephen H. Buhner includes Sida acuta in his herbal protocol treatment for Bartonellosis.

He states that this herb has broad anti-microbial effects and may treat Lyme disease and its co-infections by inhibiting the growth of pathogens, eliminating the bacteria from the body, and helping to manage the symptoms of disease(s).


Sida acuta‘s antimicrobial properties may make this an effective herb for treating Lyme disease.
lyme disease herbs - senega

8. Senega

Senega (Polygala tenuifolia) is a medicinal plant native to Asia and commonly used in Traditional Chinese Medicine (TCM).

Lyme disease expert Stephen H. Buhner explains that senega acts as an NF-kB inhibitor, meaning it can halt the bacteria’s inflammatory processes, reducing or eliminating Lyme disease symptoms.

PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders) is another condition that can be triggered by Lyme disease. According to Stephen Harrod Buhner, senega can be used to treat seizures associated with PANDAS.


Senega possesses anti-inflammatory effects that may work to reduce symptoms of Lyme disease.

Lyme Disease Herbal Protocol

Lyme disease expert and herbal author, Stephen H. Buhner developed two protocols for treating Lyme disease.

The core protocol is considered the basic or minimal support necessary for treating all aspects of Lyme disease.

The expanded/repertory protocol addresses specific symptoms, which allows you to pick and choose what is needed based on individual symptoms.

For example, if you have Lyme disease and are also experiencing anxiety, you would follow the core protocol as well as incorporate the expanded herb for anxiety:

Core ProtocolFormDosageFrequency
Japanese knotweedTincture¼ to 1 tsp.3x daily
Red sageTincture1 tsp.3x daily
Chinese skullcapTincture1 tsp.3x daily
Cat’s clawTincture¼ to ½ tsp.3x daily
CordycepsTincture½ to 1 tsp.3x daily
AshwagandhaPowder1.5 tsp.Daily
EleutheroTincture½ tsp.3x daily
LicoriceTincture¼ tsp.3x daily
AndrographisCapsule600 to 1,200 mg3x daily
Gou TengTincture½ to 1 tsp.3 to 6x daily
Non-Herbal AdditionsFormDosageFrequency
Collagen/GelatinPowder1 tbsp.Daily
Vitamin CCapsule1,000 to 3,000 mgDaily
SeleniumCapsule200 mcgDaily

Please note these dosages are only guidelines and are developed for adults, not children.

For more information on this core protocol and the expanded/repertory protocol, refer to Stephen Harrod Buhner’s book: Healing Lyme: Natural Healing of Lyme Borreliosis and the Coinfections.

What Is Lyme Disease?

Lyme disease is an illness caused by the bacterium, Borrelia burgdorferi, transmitted by an infected black-legged tick. Lyme disease can cause an array of symptoms such as a rash, fatigue, flu-like symptoms, and joint pain. 

With appropriate treatment, most people can fully recover from Lyme disease.

What are the 3 Stages of Lyme Disease?

There are three stages of Lyme disease: early localized, early disseminated, and late.

  • Stage 1: Early localized Lyme disease:
    • This stage usually occurs within 1-30 days post-tick bite. Erythema migrans (bull’s-eye rash), a low-grade fever, and flu-like symptoms may be present. 
    • Note that oftentimes a rash is present from an allergic reaction to the tick saliva. This may appear within a few hours of the tick bite and disappear within a few days; this should not be mistaken for erythema migrans.
  • Stage 2: Early disseminated Lyme disease:
    • This stage usually occurs 3-12 weeks post-tick bite. If there is a bulls-eye rash, it may now have expanded. Symptoms such as headache, fever, muscle pain, heart palpitations, eye pain, and joint pain, may be present. Meningitis and cranial nerve neuropathy may occur, in addition to extreme irritability, depression, and poor concentration.
  • Stage 3: Late Lyme disease:
    • This stage usually occurs several months to years post-tick bite. Neurological and rheumatological symptoms are typically present such as brain fog, nerve pain, muscle spasms, as well as joint swelling and pain.

How To Test for Lyme Disease?

To test for and properly diagnose Lyme disease, healthcare providers will consider the following:

  1. A history of exposure to ticks in the area
  2. A recent tick bite
  3. Signs and symptoms of Lyme disease (listed above)
  4. Blood tests (antibodies screening)

In areas where Lyme disease is prevalent, a recent tick exposure and the classic bull’s-eye rash may be all you need to start treatment (without blood work). Although in other cases, healthcare providers will want to thoroughly test with blood work, especially if the patient does not recall getting a tick bite or does not develop a rash.

Oftentimes patients can have a negative blood test result if they are tested too soon after the tick bite or infection (within the first couple of weeks). Therefore, many healthcare providers may consider treating Lyme disease without running tests or waiting for the blood work results.

For testing and diagnosing Lyme disease, contact your primary care provider (PCP) or a specialist such as a board-certified infectious disease specialist. Most doctor’s offices, walk-in-lab centers, and local laboratories such as Quest can perform Lyme disease diagnostic tests.

How Long Does Lyme Disease Last?

Fortunately, Lyme disease is treatable at any stage. How long Lyme disease lasts within the body depends on the person and case. If Lyme disease is caught early on or the tick bite is treated early, most cases can be resolved within two to four weeks.

However, many patients can develop the condition Post-Treatment Lyme Disease Syndrome (PTLDS), which is the accumulation of symptoms such as pain, fatigue, and brain fog that may last for 6 months or more post-treatment. This is thought to be due to an autoimmune response that is triggered by the bacteria, Borrelia burgdorferi.

Note that a person may continue to test positive for months or years after the bacteria is no longer in their body and symptoms are resolved. This is because the immune system continuously makes antibodies against the pathogen for months or years even after the infection is gone.

What Types of Ticks Carry Lyme Disease?

The ticks that carry Lyme disease are the black-legged ticks (the Ixodes species). In the eastern and northern United States, Ixodes scapularis ticks, also known as deer ticks, transmit Lyme disease, while in the western states, Lyme disease is transmitted by Ixodes pacificus ticks.

Is Lyme Disease Contagious?

There is no evidence indicating that Lyme disease may be contagious and transfer from person to person.

Lyme Disease During Pregnancy & Breastfeeding:

If Lyme disease is contracted during pregnancy,  it may lead to an infection of the placenta and cause harm to the fetus or baby. Getting an early diagnosis and treatment of Lyme disease is crucial during pregnancy.

There have been no adverse effects on the fetus or baby when appropriate treatment has been obtained by the mother.

In addition, no data suggests that Lyme disease can be transmitted through breast milk.

What Does Lyme Disease Look Like?

One of the first possible signs of Lyme disease is the erythema migrans (bull’s-eye rash) that develops around the site of the tick bite. This is typically a reddish or purple-colored rash, round or oval, and gradually expands. As it enlarges, the center of the rash may clear, resulting in a “bull’s-eye” look. The rash may be warm to the touch and is not typically painful. This rash is seen in about 70% of cases.

In later stages, other possible signs are “Lyme arthritis”, which is swollen knee joints, and facial palsy (facial drooping).

Common Treatment for Lyme Disease:

Treatment is based on the patient’s age and the stage of Lyme disease. The most common treatment for Lyme disease is antibiotics such as doxycycline, amoxicillin, or ceftriaxone.

Depending on the severity, two or more courses of antibiotics may be recommended by a healthcare provider. 

Doxycycline is not used in cases of children or pregnant women. Amoxicillin is typically used for children and ceftriaxone for pregnant women.


The best way to address Lyme disease is to get diagnosed and treated as early as possible. If you have had a recent tick bite and are concerned about Lyme disease, contact your healthcare provider immediately.

It is important to keep in mind that the tick must be infected in order to transmit Lyme disease and Lyme disease is treatable.

It is always recommended to consult with your healthcare provider before adding any new herbal or dietary supplement to your regimen, especially if you are pregnant or nursing, or taking any medications.

Buhner, S. H. (2015). Healing Lyme: Natural healing of Lyme borreliosis and the coinfections chlamydia and spotted fever rickettsioses (2nd edition). Raven Press: Boulder, CO.

Centers for Disease Control and Prevention (CDC): Division of Vector-Borne Diseases. (2022). Data and surveillance. U.S. Department of Health and Human Services. 

Centers of Disease Control and Prevention (CDC): Division of Vector-Borne Diseases. (2022). Lyme disease: What you need to know. U.S. Department of Health and Human Services. 

Shapiro, E. D. (2014). Borrelia burgdorferi (Lyme disease). Pediatrics in Review, 35(12), 500-509. 

Shapiro, E. D. (2014). Lyme disease. New England Journal of Medicine, 370(18), 1724-1731.,%2C%20and%20adult

Skar, G. L. & Simonsen, K. A. (2023). Lyme disease. StatPearls [Internet]. NIH National Library of Medicine: National Center for Biotechnology Information. StatPearls Publishing.

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About Tara Bassi, MS, CNS, LDN

Tara is a Licensed Nutritionist and Clinical Herbalist, specializing in women’s health. She has a Master’s of Science in Clinical Nutrition and Herbal Medicine from Maryland University of Integrative Health and is a Board Certified Nutrition Specialist (CNS®).