The Best Nattokinase Supplement | 2023 Complete Guide

Nattokinase supplements have become popular in recent years due to their various purported health benefits for cardiovascular and circulatory health. Nattokinase is an enzyme derived from natto, a traditional Japanese …

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Written by: Daniel Powers, MS
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Nattokinase supplements have become popular in recent years due to their various purported health benefits for cardiovascular and circulatory health.

Nattokinase is an enzyme derived from natto, a traditional Japanese food made from boiled soybeans that have been fermented with special bacteria. This enzyme is thought to provide a variety of cardiovascular health benefits, especailly for atherosclerosis, blood pressure, and cholesterol.

Nonetheless, further clinical research is needed to understand the implications of nattokinase dietary supplements and their safety and efficacy. It is recommended to consult a healthcare provider before adding it to your daily routine.

#1. Editor’s Choice#2. Best High
Potency Formula
#3. Best for
Heart Health
the best nattokinase supplementsthe best nattokinase supplements
Utzy NaturalsPure EncapsulationsDesigns for Health
•Easy-To-Take Capsules
•Optimal Dosing
•Made in the USA
•Patented Form of Nattokinase
•Free of Many Allergens
•Multi-Faceted Combination Formula
•3rd Party Tested

The Best Nattokinase Brands

Not sure where to turn when looking for the best nattokinase supplement? This article will guide you through several important items to consider when choosing the best nattokinase brand – we detail which brands to look for, and which ones to pass on. 

1. Nattokinase by Utzy Naturals

Utzy Natural’s nattokinase formula is a potent formula. It contains 100mg of nattokinase per softgel, the optimal amount as per clinical research. This provides 2,000 fibrinolytic units per serving.

This formula is made with a highly purified extract derived from soybeans, which helps to increase absorption and utilization.

This product comes in small, easy-to-consume softgel. Packaged in an environmentally friendly glass bottle.

Utzy Naturals is a family-owned company that focuses on creating premium natural dietary supplements. They manufacture their products in the USA, are NSF®-certified, and do extensive product testing to ensure purity and safety. 

If you’re looking to support your heart health by arterial buildup and blood pressure levels – this science-backed formula is for you. That’s why it’s our editor’s top pick as the best nattokinase supplement.

•Reseach-backed nattokinase dose•Frequently sells out
•Easy to take softgels•Only 60 servings per bottle
•2,000 fibrinolytic units per serving

2. NSK-SD® Nattokinase by Pure Encapsulations

best nattokinase supplements

Our next best selection is Pure Encapsulation’s NSK-SD® nattokinase.

This premium formulation contains the patented NSK-SD® form of nattokinase. This is the world’s first nattokinase to become available on the market, and the only nattokinase with its own published safety, efficacy, and identity data.

All of this helps to ensure a safe, potent, and effective formula. However, this adds cost. In this case, this formula is highly-priced.

Pure Encapsulations is a trusted brand that creates products that are free from unnecessary additives and many common allergens, including gluten, wheat, dairy, and more.

•Patented NSK-SD® form of nattokinase•High price
•Tested for purity & potency•Plastic bottle
•Research-based dose

3. Natto-Serrazime™ by Designs for Health

best nattokinase supplements

This formula by Designs for Health contains both nattokinase and serrapeptidase enzymes. This combination formula is great for those that are looking for a multi-faceted approach to heart health.

This product is smart in that it contains two different enzymes that may work to inhibit the formation of blood clots and plaque in the arteries.

However, this also adds cost. If you are looking for a simpler approach, it may be best to start with a straight nattokinase before adding multiple other enzymes.

Designs for Health is a trustworthy practitioner brand that has been creating quality dietary supplements for decades.

•Combination of nattokinase and serrapeptidase enzymes•High price
•3rd party tested•This combination can have a powerful effect on blood pressure for some individuals, some users will need to use caution
•Glass bottles

4. Nattokinase by NOW Foods

best nattokinase supplements

NOW’s nattokinase formula is an inexpensive, easy-to-take option for those that are new to nattokinase supplements.

This low-cost, generic nattokinase supplement is a great budget option. It contains 100mg of nattokinase per capsule with 2,000 fibrinolytic units.

NOW Foods, a renowned health and wellness brand with decades of experience, offers high-quality, natural products, including dietary supplements, vitamins, minerals, and essential oils. Their emphasis on transparency and strict quality standards, along with sustainable sourcing, has gained the trust of conscious consumers worldwide, making them a top choice for reliable well-being support.

•Inexpensive formula•Plastic bottles
•Free of most major allergens•Generic nattokinase ingredient
•Tested for purity 

What is Nattokinase?

Nattokinase is an enzyme produced by the fermentation of soybeans by the bacterium Bacillus subtilis natto. It is a fibrinolytic enzyme, which means that it can break down fibrin, a protein that plays a role in blood clotting. Nattokinase is found in natto, a traditional fermented soy food from Japan.

How Does Nattokinase Work?

Nattokinase works by breaking down fibrin, a protein that plays a role in blood clotting. Fibrin is a mesh-like substance that forms when blood clots. Nattokinase can break down fibrin by activating plasminogen, another protein that is involved in blood clot breakdown.

In addition to breaking down fibrin, research indicates that nattokinase can also inhibit the production of plasminogen activator inhibitor-1 (PAI-1), a protein that inhibits plasminogen activation. By inhibiting PAI-1, nattokinase can help to increase the amount of plasminogen that is available to break down fibrin.

Nattokinase is also thought to have other effects that may contribute to its health benefits. For example, nattokinase has been shown to increase blood flow, reduce inflammation, and protect against damage to blood vessels.

Overall, nattokinase is a natural enzyme that has a number of potential health benefits. 

health benefits of nattokinase - blood pressure

Health Benefits of Nattokinase

Nattokinase has been shown to have a number of potential health benefits, including:

  • Reduced risk of blood clots: Nattokinase can break down fibrin, which can help to prevent the formation of blood clots. Blood clots can lead to serious health problems such as heart attack and stroke.
  • Improved blood circulation: Nattokinase can help to improve circulatory health by breaking down fibrin and other proteins that can obstruct blood flow. This can help to reduce symptoms such as varicose veins, leg cramps, and cold hands and feet.
  • Improved heart health: Nattokinase may help to support cardiovascular health by reducing the risk of blood clots and improving blood circulation. This can help to reduce the risk of heart attack, stroke, and other heart problems.
  • Other potential benefits: Nattokinase has also been shown to have potential benefits for other conditions, such as high blood pressure, high cholesterol, and Alzheimer’s disease. However, more research is needed to confirm these findings.

It is important to note that there is limited scientific evidence to support the claims about the health benefits of nattokinase. More research is needed to confirm these findings. It is also important to talk to your doctor before taking any new dietary supplement, especially if you have any underlying health conditions.

You can read our in-depth article that goes over the benefits of nattokinase here.

Nattokinase Side Effects:

Since nattokinase is a derivative of soybeans, nattokinase is presumed to be safe for most individuals. For instance, a  safety study found that taking nattokinase is of low toxicological concern.

But that doesn’t mean that nattokinase is free of all safety concerns.

Since nattokinase can influence blood circulation and chemistry, it should be used with caution by certain individuals, namely:

  • Individuals with bleeding disorders – such as hemophilia, in whom nattokinase may make symptoms worse.
  • Individuals who take blood thinning medication – including warfarin, in whom nattokinase may promote bleeding and easy bruising.
  • Individuals with low blood pressure – nattokinase may cause lightheadedness, headaches, dizziness, and fainting.
  • Individuals on antihypertensive drugs – these include ACE inhibitors and calcium channel blockers, in whom nattokinase may intensify the drug’s effect, triggering hypotension.

To minimize the risk of excessive bleeding, nattokinase should also be halted at least two weeks before a scheduled surgery.

Nattokinase should not be taken by children or during pregnancy or breastfeeding because of the lack of safety data.

Nattokinase FAQs:

What is Nattokinase?

Nattokinase is an enzyme found in natto, a traditional Japanese food. It may help reduce the risk of blood clots and improve blood circulation.

How does Nattokinase work?

Nattokinase is an enzyme that breaks down fibrin, a protein that helps form blood clots. This may help reduce the risk of blood clots and improve blood circulation.

Is Nattokinase safe?

Nattokinase is generally considered safe when taken as directed. However, it can increase the risk of bleeding in people with bleeding disorders or who are taking blood thinners. It is important to talk to your doctor before taking nattokinase, especially if you have any underlying health conditions.

Can I take Nattokinase every day?

It appears to be safe to take nattokinase daily, as long as you take 100 to 200 milligrams a day. 

When should I take Nattokinase?

It is best to take nattokinase after dinner or before sleep since blood clots are more likely to be formed during the hours between midnight and the early morning.


In conclusion, Nattokinase supplements have gained popularity due to their potential health benefits, particularly for cardiovascular and circulatory health. Nattokinase is believed to aid in managing atherosclerosis, blood pressure, and cholesterol levels.

However, it is crucial to note that more extensive clinical research is required to fully understand the safety and efficacy of these supplements. Before incorporating Nattokinase into your daily routine, it is advisable to consult a healthcare provider.

Among the top recommendations for the best Nattokinase brands are Utzy Naturals, Pure Encapsulations, Designs for Health, and NOW Foods, each offering unique advantages and considerations.

As with any supplement, individual health circumstances should be taken into account to ensure safe and appropriate usage.

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About Daniel Powers, MS

Daniel has a master's degree in herbal science from the Maryland University of Integrative Health. He has a passion for herbal medicine and how it can be used to support everyday health & wellness.